Unlocking the Endocannabinoid System with Chip Paul | Beyond the Pills Podcast

Josh: Oh, welcome, welcome to this episode of Beyond the Pills. This one's gonna be a really good one, guys. Welcome back. This is the journey through the intersection of ancient wisdom and modern science to really uncover what it truly means to heal body, mind and spirit. So today matches that vibe for sure.

Today's guest is someone who embodies this mission in every way. Chip Paul is not only a wellness innovator and an endocannabinoid system expert, he's a man on a divine mission to remind us that nature already holds the cures we seek. Ooh, I love that. As the founder of TrueMedX and Neighborly Wellness and the host of Chip Talks Health, Chip is leading a movement to reclaim health sovereignty by decoding the human operating system itself: the ECS. A Tulsa Man of the Year, ordained minister, and tireless health advocate, Chip believes that the knowledge to heal has always been within us. And it's time to remind and to remember.

So get ready for a soul-stirring and science-rich conversation about healing, health for freedom, and how we can return to the blueprint of nature. Chip, welcome to the show.

Chip: Thank you, Josh. It's a pleasure to be here. And thank you for that intro. It was great. Very well done.

Josh: Well, I love reading them and I love working on them because it truly shows the essence. I was talking about this in another episode recently, where I read someone's bio and they were like, "Wow. When I hear it to my own self, there's this power that comes from it." Because we speak our truth, we speak all those things you do when you do what you do, right? But hearing it and then absorbing that is powerful.

So let's get into it. You've got a lot going on. I've been a student of and gone on the deep dives on the endocannabinoid system for a long time. It's obviously front and center with medical marijuana and all the things going on. But your background is as unique as your mission is. So let's talk about your pathway, advocacy, and ECS research—how that led you down this path. I think people need that backstory first. Then we can dive into the other stuff. So let's start with: who are you, and how the heck did you get here?

Chip: Yeah, that sounds good. So I'm a mathematician by training and I've always been a "why guy." I've always wanted to dive in and figure things out. I had some experience with free energy back in the late '90s and early 2000s, which was really interesting. So I've always been someone who dives in and tries to understand a topic. Frequency has always fascinated me.

In 2013, my wife and I were teetotalers. We didn’t drink alcohol, we didn’t smoke marijuana. We didn’t even really take medicine—maybe an Advil if my back hurt. But we were both in a lot of pain. She was a two-level spinal fusion patient. And we knew that something was in our future as far as pain management.

We made a very intentional and thoughtful decision to drive to Colorado and try medical marijuana. Though I think I can now say we actually bought some on the black market here in Oklahoma and tried it before we made it legal. But that started a whole journey. And it worked—in a way that fascinated me. That piqued my curiosity.

I began to study why medical marijuana worked. It works because it impacts something called the endocannabinoid system. But really, the ECS needs to be divorced from marijuana. Cannabis is a way to impact the system, but the system itself is much broader and more fundamental. It’s our master regulatory system. It exists in everything with a spine. It’s present in every cell and every organelle in the body. It has to be if it’s truly the master regulatory system.

It is the therapeutic target of the future. Every scientist, researcher, pharmacist, doctor, and nutritionist should know it. Intimately.

Josh: Yes! And I think when we started talking, you sparked my interest. People think cannabis affects the system rather than understanding that the system is affected by cannabis—it’s already there. This system is very new to modern science, even though it’s always existed.

I like to say, if you affect the power grid, you affect the whole system. Not just one pole. This system is like the grid. So let's talk about what kind of things play into the ECS and how we can use it.

Chip: Great analogy. If you look at something like semaglutides, they're trying to get cells to express GLP1, GIP, and peptide YY. But there's actually an endocannabinoid receptor—GPR120—that controls all of that. It’s a better, safer, more efficacious target.

Let me describe what the ECS is and how it works. Cells are like little individual people. They can be happy and social and want to join a collective—say, to form a heart. But if the environment is bad, they’ll isolate. When a cell wants to be part of the system, it pops up a CB1 receptor, signaling, "I want to play. I want to be part of the collective."

Under oxidative stress or inflammation, cells feel threatened. So they pull in those CB1 receptors. Cancer is the extreme case—a cell goes rogue and forgets it’s part of the whole.

Josh: Wow, that analogy is so good. It’s just like us—if we’re not safe, we don’t collaborate. Cells do the same. They shut down when threatened. The ECS is like the nervous system of that collective.

Chip: Exactly. Your body is like a symphony, and the ECS is the conductor. The hypothalamus and hippocampus are like the computer. The ECS senses the environment—diet, stress, infection—and modulates accordingly.

Josh: It’s a balancing system, always regulating. And environmental inputs really do matter. So what are some overlooked ways the ECS ties into gut health, emotional regulation, or chronic disease?

Chip: Great question. First, the ECS is not fed by marijuana—it’s fed by dietary fats. Saturated fat, monounsaturated fat, omega-3 and omega-6 fats. Our bodies can’t make omega-3 and omega-6 fats—they’re essential.

Here’s the kicker: most of us eat a 40:1 ratio of omega-6 to omega-3. That creates a hyper-inflammatory state. Every cell wall in your body reflects your omega fat intake. Omega-6 is fire. Omega-3 is water. In balance, they work. Out of balance? Inflammation, pain, immune overreaction.

If you eat balanced fats and you have a dust allergy, you might sneeze during a storm but recover quickly. If you eat 40:1 omega-6, a dust storm could hospitalize you. That’s how extreme the imbalance is.

Josh: This is so powerful. I test Omega-3 indexes in my practice and have always pushed omega-3s. But this ties it to the ECS—makes it even more critical. Root cause medicine starts here.

Chip: And yes, that imbalance sets the tone for immune dysfunction. So we get infected more easily. Parasites, viruses, bacteria—our immune system is distracted. Grandma didn’t die of a heart attack. She died of a 30-year hookworm infection that weakened her heart.

Josh: That’s a powerful reframe. Our current system just names the symptom and throws a med at it. Pharma has a place—if I get hit by a bus, take me to the ER. But for chronic disease? We need this root-level view.

Chip: Yep. Fasting, for example, activates AMPK, which mimics what drugs do—without the side effects. Statins are trying to block cholesterol production. But high LDL just means your body is trying to heal. Infection or trauma is calling for more cholesterol.

Josh: Yes! Cortisol, cholesterol—all of it ties to stress and survival. And the system only works if upstream inputs are regulated. That’s why I love energy medicine too. Because frequency matters.

Chip: Absolutely. We are energetic beings. The ECS is the interface between energy and biology. Our cells respond to frequency. If you study this system, you start to understand diet, environment, stress—all of it. It’s a gateway to whole-person healing.

Josh: You’re an ordained minister. I want to ask: how do you see the divine blueprint of biology through the ECS?

Chip: Great question. If I clean my temple, I can pour more of my spirit into this body. When we heal the physical, we increase our spiritual power. The ECS connects us to that higher state.

Walter Russell’s work, for example, explains how light and frequency precipitate into matter. We are light, slowed down. If we optimize our frequency and nourish our ECS, we begin to glow with that inner music.

Josh: Goosebumps. This is what healing is really about. Body, mind, and spirit. The ancient and the modern together. We’re finally in a golden age of understanding.

Chip: Yes. And that’s what we do at TrueMedX and Neighborly Wellness. Our supplements are ECS-driven. We use terpenes, oils, herbs—things from nature that impact this master system. We’re working to prove them out and bring them into the healthcare system.

Josh: And people can find you at truemedx.com and neighborlywellness.com, right?

Chip: Correct. And if people are interested in opening wellness hubs or partnering on care protocols, reach out. We’re building a network.

Josh: Let’s go. The future is functional. The future is frequency. The future is freedom through understanding. Thanks, Chip. This was amazing.

Chip: Thank you, Josh. I appreciate it.

Josh: Until next time, stay well.

The Endocannabinoid System is the body's main regulatory network, coordinating inflammation, immune response, pain, hormone balance, and cellular communication.

No. Cannabis interacts with the ECS, but the ECS exists regardless of cannabis . It can be influenced through food, environment, infection, and stress.

Dietary fats—especially omega-3 and omega-6—are primary. You need them in the right ratio (ideally 1:1 to 4:1) to maintain ECS function.

Too much omega-6 creates chronic inflammation. The ECS uses fats to create signaling molecules like prostaglandins that regulate pain and inflammation.

• Chronic pain or inflammation

• Immune dysregulation or frequent illness

• Anxiety or sleep issues

• Gut imbalance

• Hormone dysfunction

Yes. Compounds like CBD, turmeric, black seed oil, and terpenes like beta-caryophyllene help support ECS tone and balance.

TrueMedX formulas are:

• Scientifically formulated based on ECS pathways

• Built from natural compounds with specific receptor actions

• Supported by patents and clinical insight

• Designed to retrain the body rather than override it

Visit Neighborly Wellness for bioresonance scans, consultations, and ECS-aware health protocols.